适体介导的药物靶向递释系统的研究进展

张弛,张奇志

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (3) : 161-164.

PDF(820 KB)
PDF(820 KB)
中国药学杂志 ›› 2013, Vol. 48 ›› Issue (3) : 161-164. DOI: 10.11669/cpj.2013.03.001
综 述

适体介导的药物靶向递释系统的研究进展

  • 张弛,张奇志
作者信息 +
文章历史 +

摘要

目的 综述适体(aptamers)在介导药物靶向递送方面的研究进展。 方法 查阅近年来国内外相关文献,对适体的产生及特点进行阐述,并整理、分析和归纳其在药物靶向递送系统中的应用。 结果与结论 适体是一类能与许多生物大分子或细胞特异性结合的核酸分子,能够介导药物或载体到达特定的器官、组织甚至细胞,从而提高药物在靶组织/靶细胞的浓度,为药物靶向递送系统的研究提供了新的思路和方向。

关键词

适体 / 靶向递送系统 / 特异性

引用本文

导出引用
张弛,张奇志. 适体介导的药物靶向递释系统的研究进展[J]. 中国药学杂志, 2013, 48(3): 161-164 https://doi.org/10.11669/cpj.2013.03.001
中图分类号: R944   

参考文献

[1] YANG L, ZHANG X, YE M,et al. Aptamer-conjugated nanomaterials and their applications. Adv Drug Deliv Rev, 2011, 63(14-15): 1361-1370.
[2] PROSKE D, BLANK M, BUHMANN R,et al. Aptamers-basic research, drug development, and clinical applications. Appl Microbiol Biotechnol, 2005, 69(4): 367-374.
[3] ELLINGTON A D, SZOSTAK J W. In vitro selection of RNA molecules that bind specific ligands. Nature, 1990, 346(6287): 818-822.
[4] TUERK C, GOLD L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science, 1990, 249(4968): 505-510.
[5] BUNKA D H, STOCKLEY P G. Aptamers come of age - at last. Nat Rev Microbiol, 2006, 4(8): 588-596.
[6] SHANGGUAN D, LI Y, TANG Z,et al. Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci USA, 2006, 103(32): 11838-11843.
[7] GUTSAEVA D R, PARKERSON J B, YERIGENAHALLY S D,et al. Inhibition of cell adhesion by anti-P-selectin aptamer: A new potential therapeutic agent for sickle cell disease. Blood, 2011, 117(2): 727-735.
[8] HUANG Y F, SEFAH K, BAMRUNGSAP S,et al. Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods. Langmuir, 2008, 24(20): 11860-11865.
[9] YANG C X,GE Z Q.Research and development of aptamers acting as drug targeting carriers. Chin Med Biotechnol(中国医药生物技术), 2010, 5(4): 297-299.
YANG L, ZHANG X, YE M,et al. Aptamer-conjugated nanomaterials and their applications. Adv Drug Deliv Rev, 2011, 63(14-15): 1361-1370.
TAN W, WANG H, CHEN Y,et al. Molecular aptamers for drug delivery. Trends Biotechnol, 2011, 29(12): 634-640.
ZHANG Y, CHEN Y, HAN D,et al. Aptamers selected by cell-SELEX for application in cancer studies. Bioanalysis, 2010, 2(5): 907-918.
JAYASENA S D. Aptamers: An emerging class of molecules that rival antibodies in diagnostics. Clin Chem, 1999, 45(9): 1628-1650.
GROUP E S. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase II study results. Ophthalmology, 2003, 110(5): 979-986.
RUCKMAN J, GREEN L S, BEESON J,et al. 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J Biol Chem, 1998, 273(32): 20556-20567.
DOGGRELL S A. Pegaptanib: The first antiangiogenic agent approved for neovascular macular degeneration. Expert Opin Pharmacother, 2005, 6(8): 1421-1423.
MONGELARD F, BOUVET P. AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia. Curr Opin Mol Ther, 2010, 12(1): 107-114.
KEEFE A D, PAI S, ELLINGTON A. Aptamers as therapeutics. Nat Rev Drug Discov, 2010, 9(7): 537-550.
BOUCHARD P R, HUTABARAT R M, THOMPSON K M. Discovery and development of therapeutic aptamers. Annu Rev Pharmacol Toxicol, 2010, 50: 237-257.
EULBERG D, KLUSSMANN S. Spiegelmers: Biostable aptamers. Chembiochem, 2003, 4(10): 979-983.
FAMULOK M, MAYER G, BLIND M. Nucleic acid aptamers-from selection in vitro to applications in vivo. Acc Chem Res, 2000, 33(9): 591-599.
CHEN X C, DENG Y L, LIN Y,et al. Quantum dot-labeled aptamer nanoprobes specifically targeting glioma cells. Nanotechnology, 2008, 19(23): 235105.
KO H Y, CHOI K J, LEE C H,et al. A multimodal nanoparticle-based cancer imaging probe simultaneously targeting nucleolin, integrin alphavbeta 3 and tenascin-C proteins. Biomaterials, 2011, 32(4): 1130-1138.
SUN Z, WANG Y, WEI Y,et al. Ag cluster-aptamer hybrid: Specifically marking the nucleus of live cells. Chem Commun (Camb), 2011, 47(43): 11960-11962.
ZUO J M, LI B Q. Nanostructure evolution during cluster growth: Ag on H-terminated Si(111) surfaces. Phys Rev Lett, 2002, 88(25 Pt 1): 255502.
HUANG Y F, SHANGGUAN D, LIU H,et al. Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. Chembiochem, 2009, 10(5): 862-868.
CHU T C, MARKS J R, LAVERY L A,et al. Aptamer: Toxin conjugates that specifically target prostate tumor cells. Cancer Res, 2006, 66(12): 5989-5992.
MEYER C, EYDELER K, MAGBANUA E,et al. Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells. RNA Biol, 2012, 9(1): 67-80.
TAN W, WANG H, CHEN Y,et al. Molecular aptamers for drug delivery. Trends Biotechnol, 2011, 29(12): 634-640.
ZHOU J, LI H, LI S,et al. Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther, 2008, 16(8): 1481-1489.
WULLNER U, NEEF I, ELLER A,et al. Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2. Curr Cancer Drug Targets, 2008, 8(7): 554-565.
MCNAMARA J N, ANDRECHEK E R, WANG Y,et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol, 2006, 24(8): 1005-1015.
CAO Z, TONG R, MISHRA A,et al. Reversible cell-specific drug delivery with aptamer-functionalized liposomes. Angew Chem Int Ed Engl, 2009, 48(35): 6494-6498.
MANN A P, BHAVANE R C, SOMASUNDERAM A,et al. Thioaptamer conjugated liposomes for tumor vasculature targeting. Oncotarget, 2011, 2(4): 298-304.
KATAOKA K, HARADA A, NAGASAKI Y. Block copolymer micelles for drug delivery: Design, characterization and biological significance. Adv Drug Deliv Rev, 2001, 47(1): 113-131.
WU Y, SEFAH K, LIU H,et al. DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells. Proc Natl Acad Sci USA, 2010, 107(1): 5-10.
PING S, LAI C. AS1411 Aptamer-conjudated polymeric micelle for targetable cancer therapy. NSTI-Nanotech, 2010,(3): 330-333.
MATHEW A, ARAVIND A, BRAHATHEESWARAN D,et al. Amyloid-binding aptamer conjugated curcumin-PLGA aanoparticle for potential use in alzheimer′s disease. Bio Nano Sci, 2012,2(2):83-93.
GUO J, GAO X, SU L,et al. Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery. Biomaterials, 2011, 32(31): 8010-8120.
GAO H, QIAN J, CAO S,et al. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials, 2012, 33(20): 5115-5123.
ZHOU J, ROSSI J J. Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides, 2011, 21(1): 1-10.
VAN DEN BOSSCHE J, AL-JAMAL W T, TIAN B,et al. Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. Chem Commun (Camb), 2010, 46(39): 7379-7381.
KANG H, TRONDOLI A C, ZHU G,et al. Near-infrared light-responsive core-shell nanogels for targeted drug delivery. ACS Nano, 2011, 5(6): 5094-5099.
PDF(820 KB)

Accesses

Citation

Detail

段落导航
相关文章

/